Atlético's derby precedent: 4-0 against Madrid in the Calderón
Diego Simeone's side need to score at least three without reply against Real Madrid to have any chance of reaching the Champions League final.
Atlético Madrid face a mammoth task to reach the Champions League final at the expense of local rivals Real Madrid after going down 3-0 in the Bernabéu to a Cristiano Ronaldo hat-trick.
Diego Simeone's side have a recent precedent for the task at hand, having beaten Real 4-0 in the Calderón in a league game two seasons ago.
Antoine Griezmann, Mario Mandzukic, Tiago and Saúl were all on target on February 7, 2015, a result that Colchoneros will look to for inspiration on Wednesday night.