Real Madrid will host Barcelona on 30 January in the first leg of the semi-finals of the Copa del Rey, and Tito Vilanova's side are the favourites to win the match.
Barça's 15 point lead over Madrid in the league and the fact that José Mourinho's side will be without key players Sergio Ramos, Fabio Coentrao and Ángel Di María due to suspension and Iker Casillas and Pepe due to injury seem to be key factors in the Catalans being seen as the team more likely to win.
A Madrid win will yield over 2.60 euros for every euro bet, while a Barcelona victory will return 2.50 per euro.
Although Barcelona are the favourites according to all bookmakers, the differences between a victory for either team are minimal, and the best odds are offered on a draw, which will return 3.60 euros for every euro bet.
Barcelona are not just favourites to win the first leg at the Bernabéu, however, but to win the whole competition.
If 'Los Culés' lift the cup, punters who put money on them will receive 2.25 euros for every euro put down. Madrid are the second favourites, at 3.25 euros. The odds on Atlético Madrid to win the historic trophy are only slightly longer, at 3.75 euros, while Sevilla remain the clear outsiders, at 12 euros for every euro placed.