José Mourinho will give a run out to a number of Madrid's academy players against Alcoyano, and will rest many of his first team players, with the derby against Atlético Madrid on Saturday in mind.
Mesut Özil, Luka Modric and José Callejón are the only usual starters to make the starting line-up, while Denis Cheryshev makes his debut for Madrid, becoming the first ever Russian to play for 'Los Blancos'.
Real Madrid starting XI: Adán; Albiol, Varane, Carvalho, Nacho; Modric, José Rodríguez; Callejón, Özil, Cheryshev; Morata
Alcoyano starting XI: Murcia, Arkaitz, Javi Selva, O.López, Devesa, David Torres, Omar, Pereira, Lara, Dani, Tortosa.
Real Madrid lead 4-1 on aggregate in the tie.